In 1988, Leoni casts in the upgraded version of 1970s show Charlie’s Angels. However, the show never aired. As Lisa DiNapoli, she cast in the NBC daytime opera Santa Barbara in 1990. Finally, in 1991, she made her debut in the movie Switch.
Following her minor success, she played a small part in A League of Their Own. In 1992, she along with Corey Parker starred in the Fox Sitcom Flying Blind until 1993. She then appeared in the female leading role in the movie Bad Boys in 1995.
Following the success of Bad Boys, she cast in the movie Deep Impact. Later, she starred alongside Nicolas cage in romantic comedy movie The Family man, before casts in Sci-fi movie Jurassic Park III.
From 2002 – 2005, she cast in several movies that include Hollywood Ending, People I Know, Spanglish and Fun with Dick and Jane. Additionally, she featured in numerous short films including You Kill Me and The smell of Success.
In 2008, she co-starred in supernatural movie Ghost Town. She also featured in the 2011 comedy movie Tower Heist. Once again, she returned to broadcast television, following the leading role in the Madam Secretary, the 2014 political drama series.
Leoni is very passionate and dedicated actress. With her remarkable performance, she has won as well as nominated for several Awards. In 1998 & 2000, she was nominated for the Blockbuster Entertainment Awards for Favorite actress – Sci-Fi.
She was awarded 2000s Saturn Awards for Best Actress for the movie The Family Man. From 2006 to 2016, she was nominated for four different awards that include TV Land Awards, Alliance of Women Film Journalists Awards, People’s Choice Awards and CBS MVP Awards.