Menounos became a producer of In the Land of Merry Misfits directed by Keven Undergaro. But the film’s negative was stole and the project remained uncompleted. Fortunately, Channel One News hired her considering her sincerity for her work. In 2005, she personally invested for the film which was premiered at Tribeca Film Festival in 2007.
As a reporter for Channel One News, she traveled to El Salvador for the coverage of 2001 El Salvador earthquakes. During the military alliance’s Operation Eagle Assist, she became interviewed the NATO aircrew member abroad an E-3 AWACS plane also, interviewed the then president of United states George W. Bush.
She served for the program Entertainment Tonight as a correspondent. Later, she quit the show to focus on her acting career. She joined Access Hollywood as a correspondent and became the co-anchor of the Today at the end of 2006 and in April 2007 for few episodes. She also appeared in Punk’d where she was among various celebrities who grabbed in discomfiting ‘Red Carpet Interviews’ on 30 November 2003.
She has appeared in numerous TV series starting from the year 2004 with One on One in the role of Glenda, One Tree Hill (2004-2005) as Emily. Later, she appeared in several others such as Scrubs, Entourage, Knight Rider, Sesame Street, The Mindy Project, Nashville, Bar Rescue, and Chasing Maria Menounos, which was her own reality TV series premiered on the Oxygen Network.
She has worked as a voice artist for Electronic Arts, a video game in 2005, as Eva Adara for James Bond 007: From Russia with Love, Red Grant’s henchwoman. She is engaged with Pantene hair products as its spokesperson plus print ads for New York & Company and became an anchor for 2006 Eurovision Song Contest in Athens. She produced as well as performed in Adventures of Serial Buddies and directed Longtime Listener casting Wilmer Valderrama which was officially selected by Tribeca Film Festival 2006.
She has also appeared as host for Clash of the Choirs from 17-20 December 2007 including others shows such as Planet Green network’s Hollywood Green, Funny or Die Presents, MTV’s The Real World as well as The Challenge etc. She made a guest appearance in the movies such as Tropic Thunder (2008), Adventures of Serial Buddies as Katelyn (2011), Entourage (2015).
Moreover, Menounos also participated in various reality shows including AVP Cuervo Gold Crown Huntington Beach Open in 2008. The same year, she worked as fill-in host of Dogcatemy Celebrity Gala for North Shore Animal League due to a poor health condition of Richard Belzer. In 2011, she became co-host of Extra for Warner Bros along with Mario Lopez and worked for Dr. Drew’s Lifechangers. She produced her new interview show Conversation with Maria Menounos in May 2013 making Zoe Saldana her first guest.
In May 2014, she joined E!Entertainment after resigning the show Extra. She also hosted a radio program Conversations with Maria for SiriusXM in 2015 and also replaced Giuliana Rancic for The Hollywood Reporter’s E!News. Later in July 2017, she left E!News after diagnosing a brain tumor.
Additionally, Maria made her debut in wrestler’s world as a guest host of WWE Raw on October 12, 2009, along with Nancy O’Dell. At the same night, she came to the ring in a six diva tag team playoffs along with Gail Kim and Kelly Kelly where they defeated Alicia Fox, Beth Phoenix and Rosa Mendes. In the match WWE Tribute to the Troops on 11 December 2011, Maria team won over The Bella Twins and The Divas of Doom.
Her ribs were cracked through the practice session of Dancing with the Stars despite that she and Kelly beat WWE Divas Champion Beth Phoenix and Eve Torres in WrestleMania XXVII on April 1, 2012. She introduced Bob Backlund at Madison on 6 April 2013. In the Summerslam Axxess in 2013, Maria along with Natalya succeeded defeating Brie Bella and Exa Marie.
She also dared to Stephanie McMahon for ALS Ice Bucket Challenge during the SummerSlam pay-per-view on 17 August 2014. Since 2014-17, she became the host for WWE Hall of Fame and also a backstage interviewer for WrestleMania 31, WrestleMania 32, WrestleMania 33 and SummerSlam. She is also an author for the EVERYGIRL’S GUIDE book series which is about cooking, fitness and life hacks for girls.